助理教授

个人介绍：

韩炎，男，深圳技术大学药学院助理教授。2016年本科毕业于长春中医药大学中医学专业，2019年硕士毕业于北京中医药大学中西医结合基础专业，2024年博士毕业于澳门大学生物医药专业，于2024年9月加入深圳技术大学药学院，主要研究方向为肠道菌群和神经认知障碍，运用多组学分析（宏基因组学、代谢组学、蛋白质组学等）技术探究认知障碍老人肠道菌群代谢特征变化，及相关诊断标志物的发现。目前已经发表SCI论文10余篇，申请专利3项，参与多项省市级研发项目。

科研项目：

1.澳门科学技术发展基金项目：基于多源异构多模数据融合构建阿尔茨海默病早期识别的智能辅助系统，2024/01−2026/12，170万澳门元，在研，参与。

2.澳门科学技术发展基金项目：澳门认知功能障碍长者中医“体-病-证”辨识与肠道微生物组学和代谢组学特征性变化的相关性研究，2019/01−2022/12，150万澳门元，已结题，参与。

3. G20工程医药产业创新研发：治疗缺血性脑卒中中药1类新药佳思明尼的临床前研究，2018/01−2020/12, 50万，已结题，参与。

4.北京市科委十病十药研究专项：防治抑郁症中药1类新药洛安宁的临床前研究, 2017/01−2020/06, 50万，已结题，参与。

代表成果：

1. Han Yan, Zeng Xinglin, Hua Lin, Quan Xingping, Chen Ying, Zhou Manfei, et al. The fusion of multi-omics profile and multimodal EEG data contributes to the personalized diagnostic strategy for neurocognitive disorders [J].Microbiome, 2024, 12(1): 12. (IF: 15.5)

2. Han Yan, Quan Xingping, Chuang Yaochen, Liang Qiaoxing, Li Yang, Yuan Zhen, et al. A multi‐omics analysis for the prediction of neurocognitive disorders risk among the elderly in Macao [J].Clinical and Translational Medicine, 2022, 12(6): e909. (IF: 10.6)

3. Han Yan, Chen Ying, Zhang Qian, Liu Bowen, Yang Li, Xu Youhua, et al. Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke [J].Phytomedicine, 2021, 90: 153652. (IF: 7.9)

4. Shi Rui,Han Yan (co-first author), Yan Yu, Qiao Haoyi, He Jun, Lian Wenwen, et al. Loganin exerts sedative and hypnotic effects via modulation of the serotonergic system and GABAergic neurons [J]. Frontiers in Pharmacology, 2019, 10: 409. (IF: 5.6)

5. Quan Xingping,Han Yan, Lu Pengde, Ding Yuanfu, Wang Qingfu, Li Yiyang, et al. Annexin V‐Modified Platelet‐Biomimetic Nanomedicine for Targeted Therapy of Acute Ischemic Stroke [J].Advanced Healthcare Materials, 2022, 11(16): 2200416. (IF: 10.0)

6. Quan Xingping, Liang Xiao, Ding Yuanfu,Han Yan, Li Junyan, Yuan Mengchen, et al. Cryo-Shocked Platelet Coupled with ROS-Responsive Nanomedicine for Targeted Treatment of Thromboembolic Disease [J].ACS Nano, 2023, 17(7): 6519-6533. (IF: 17.1)

7. Li Yiyang, Liu Bowen, Zhao Tingting, Quan Xingping,Han Yan, Cheng Yaxin, et al. Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood–brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke [J].Journal of Nanobiotechnology, 2023, 21(1): 1-19. (IF: 10.2)

8. Liu Bowen, Li Yiyang,Han Yan, Wang Shengpeng, Yang Hua, Zhao Yonghua, et al. Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke [J].Phytomedicine, 2021, 90: 153660. (IF: 7.9)

9. Pengde Lu, Jinfen Chen, Ying Chen, Xingping Quan, Jiayue Liu,Yan Han, et al. 20 (S)‐Protopanaxadiol saponins isolated from Panax notoginseng target caveolin‐1 against intestinal barrier dysfunction by alleviating inflammatory injury and oxidative stress in experimental murine colitis[J].Food Frontiers, 2023, 4(4): 2081-2096. (IF: 9.9)

10. Yiyang Li, Jiali Chen, Xingping Quan, Ying Chen,Yan Han, et al. Extracellular Vesicles Maintain Blood-Brain Barrier Integrity by the Suppression of Caveolin-1/CD147/VEGFR2/MMP Pathway After Ischemic Stroke [J].International Journal of Nanomedicine, 2024;19:1451-1467. (IF: 8.0)

11. Liu Bowen, Zhao Tingting, Li Yiyang,Han Yan, Xu Youhua, Yang Hua, et al. Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia [J].Phytotherapy Research, 2022, 36(5): 2223-2235. (IF: 7.2)

12. Li Yiyang, Liu Bowen, Chen Ying, Quan Xingping,Han Yan, Zheng Ying, et al. Extracellular vesicle application as a novel therapeutic strategy for ischemic stroke [J].Translational Stroke Research, 2021: 1-17. (IF: 6.9)

联系方式：

hanyan@sztu.edu.cn