助理教授
个人介绍:
黄小兵,男,深圳技术大学药学院助理教授。2013年本科毕业于广州中医药大学制药工程专业,2016年硕士毕业于中国科学院昆明植物研究所药学专业,2021年博士毕业于澳门大学生物医药专业。2021年10月至2024年7月在暨南大学从事博士后研究工作,于2024年9月加入深圳技术大学药学院,研究方向为衰老和神经退行性疾病。主要采用秀丽线虫为模型,评价化合物药效及作用机制,目前已经发表SCI论文10余篇,主持国家自然科学基金青年基金,参与多项国家级研发项目。
近年主要科研项目:
1.国家自然科学基金青年基金, 32400781, DNA 6mA甲基化修饰调控帕金森病发病机制研究, 2025-01-01至2027-12-31,在研,主持
2.国家自然科学基金面上项目, 32370415,基于秀丽线虫对橘叶中抗衰老成分的挖掘及机制研究, 2024-01-01至2027-12-31,在研,参与
3.国家自然科学基金面上项目, 82270600,紧密连接蛋白TJP2通过调控染色质三维结构导致胆汁淤积症, 2023-01-01至2026-12-31,在研,参与
代表论文:
1.Huang XB#,Ye QS#, Dai WY#, Zheng JM, Li YM, Wang C, Luo ZH, Yang J, Zhuo WY, Wan QL. Cadmium exposure induces multigenerational inheritance of germ cell apoptosis and fertility suppression inCaenorhabditis elegans. Environment International, 2024. 191:108952.
2.Huang XB,Wang CL, Zhang TJ, Li RZ, Chen L, Leung KL, Lakso M, Zhou QH, Zhang HJ, Wong G. PIWI-interacting RNA expression regulates pathogenesis in aCaenorhabditis elegansmodel of Lewy body disease. Nature Communications, 2023. 14(1): 6137.
3.Huang XBand Wong G. An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases. Translational Neurodegeneration, 2021. 10(1): 9.
4.Huang XB,Wang CL, Chen L, Zhang TJ, Leung KL, Wong G. Human amyloid beta and α-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia inCaenorhabditis elegans. BBA-Molecular Basis of Disease, 2021.1867(10): 166203.
5.Huang XB,Wu GS, Ke LY, Zhou XG, Wang YH, Luo HR. Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins inCaenorhabditis elegans. Molecules, 2018. 23(6): 1359.
6.Huang XB,Mu XH, Wan QL, He XM, Wu GS, Luo HR. Aspirin increases metabolism through germline signalling to extend the lifespan ofCaenorhabditis elegans. PLoS One, 2017. 12(9): e0184027.
7.Zheng SQ#,Huang XB#(co-first), Xing TK, Ding AJ, Wu GS, Luo HR. Chlorogenic Acid Extends the Lifespan ofCaenorhabditis elegansvia Insulin/IGF-1 Signaling Pathway. Journals of Gerontology: Biological Sciences, 2017. 72(4): 464-472.
8.Li RZ,Huang XB,Shen LJ, Zhang TJ, Liu N, Hou XQ, Wong G. NovelC. elegansmodels of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation. Cellular and Molecular Life Sciences, 2024. 81:377.
9.Yang J,Huang XB,Wan QL, Ding AJ, Yang ZL, Qiu MH, Sun HY, Qi SH, Luo HR. Otophylloside B protects against Aβ toxicity inCaenorhabditis elegansmodels of Alzheimer’s disease. Natural Products and Bioprospecting, 2017. 7(2):207-214.
10.Ding AJ, Zheng SQ,Huang XB,Xing TK, Wu GS, Sun HY, Qi SH, Luo HR. Current Perspective in the Discovery of Anti-Aging Agents from Natural Products. Natural Products and Bioprospecting, 2017. 7(5):335-404.
联系方式:
huangxiaobing@sztu.edu.cn