助理教授
个人简介:
付雨,助理教授。2021年获得华中科技大学博士学位,博士在读期间赴中科院生物物理研究所王江云研究员课题组联合培养。主要研究领域及兴趣包括构建人工酶催化生化合成反应、计算机辅助人工酶设计、光生物催化、生物兼容性合成方法的开发等。截止目前在包括Chem、J. Am. Chem. Soc.、ACS Sustainable Chem. Eng.、Org. Biomol. Chem.等国际知名学术期刊发表10余篇学术论文,以项目负责人身份主持中国博士后科学基金站中特别资助、中国博士后科学基金面上资助及华中科技大学创新研究院技术创新基金项目,并参与国家重点研发计划2018年度合成生物学重点专项项目等课题研究。
科研项目:
(1)中国博士后科学基金第16批站中特别资助(2023T160239,18万),基因编码改造烯烃还原酶催化未活化芳烃不对称去芳构化反应。2022.12-2023.12,主持,结题
(2)中国博士后科学基金第71批面上资助(2022M711245,8万),基因编码改造烯烃还原酶催化不对称自由基氢芳基化反应。2022.6-2023.9,主持,结题
(3)华中科技大学创新研究院2018年技术创新基金立项(2018JYCXJJ040,5万),不同形状DNA纳米颗粒的构建及其对细胞摄取的影响研究。2018.6-2020.6,主持,结题
(4)国家重点研发计划2018年度“合成生物学”重点专项“非金属活性中心人工酶的构筑及手性生物合成研究”项目(2018YFA0903500,476万)。2019.7-2024.6,在研,参与
代表成果:
1.Yu Fu#, Xiaohong Liu#, Yan Xia, Xuzhen Guo, Juan Guo, Junshuai Zhang, Weining Zhao, Yuzhou Wu, Jiangyun Wang*, Fangrui Zhong*, Whole-cell-catalyzed hydrogenation/deuteration of aryl halides with a genetically repurposed photodehalogenase.Chem2023, 9(7), 1897-1909. (IF = 25.8)
2.Yu Fu#, Jian Huang#, Yuzhou Wu*, Xiaohong Liu*, Fangrui Zhong*, Jiangyun Wang*, Biocatalytic cross-coupling of aryl halides with a genetically engineered photosensitizer artificial dehalogenase.J. Am. Chem. Soc.2021, 143(2), 617-622. (IF = 16.38)
3.Yu Fu; Yan Xia; Yingru Xu; Xutong Ye; Shangxian Xie; Yuzhou Wu; Weining Zhao*; Fangrui Zhong*; A recyclable supramolecular photocatalyst for the chemoselective [2+2] photocycloaddition of chalcones in water,ACS Sustainable Chem. Eng.2023,11(50), 17752-17759. (IF = 8.4)
4.Yu Fu, Qile Yu, Yulong Zhang, Zhonghong Gao*, Yuzhou Wu*, Fangrui Zhong*, Hemin-catalyzed biomimetic oxidative phenol-indole [3+2] reactions in aqueous media.Org. Biomol. Chem.2019, 17(47), 9994-9998. (IF = 3.89, highlighted by synfacts)
5.Yu Fu, Fangrui Zhong *. Recent advances in chemically driven enantioselective photobiocatalysis.Synthetic Biology Journal,2024.
6. Huaibin Yu, Shuangshuang Wang,Yu Fu, Manfred Wagner, Tanja Weil, Shaoqin Liu*, Weining Zhao, Fangrui Zhong, Yuzhou Wu*. Spatiotemporally controlled photolabeling of genetically unmodified proteins in live cells.Anal. Chem.2024. (IF = 7.4)
7. Shuangshuang Wang, Huaibin Yu, Longjie Li, Meizhou Zhang,Yu Fu, Zi’an Lin, Jinsheng Li, Fangrui Zhong, Hongmei Liu*, Yuzhou Wu*. Fluorescent turn-on probes for visualizing GPx4 levels in live cells and predicting drug sensitivity.Anal. Chem.2023, 95(23), 8939-8947. (IF = 7.4)
8. Qile Yu,Yu Fu, Jianjian Huang, Jingyang Qin, Honghua Zuo, Yuzhou Wu*, Fangrui Zhong*, Enantioselective oxidative phenol-indole [3+2] coupling enabled by biomimetic Mn (III)/bronsted acid relay catalysis.ACS Catal.2019, 9(8), 7285-7291. (IF = 13.7)
联系方式:
fuyu@sztu.edu.cn