助理教授
个人介绍:
王佳,深圳技术大学药学院助理教授,硕士生导师。博士毕业于北京师范大学,后于英国邓迪大学从事博士后研究工作。研究领域:基于结构生物学与生物计算进行药物筛选和开发。发表SCI论文19篇,其中以第一作者或通讯作者发表SCI研究论文共9篇。其中,影响因子>10的3篇,Cell子刊两篇。作为负责人主持了国家自然科学基金青年科学项目和中国博士后基金特别资助项目以及广东省重点研发项目子课题等多项科研项目,具有丰富的主持科研项目的经验。
科研项目:
1. 2020年国家自然科学基金青年项目“米曲霉脂肪酶AOL的偏甘油酯底物识别的分子机制”(项目号:32001639),24万,主持已结题
2. 中国博士后科学基金第14批特别资助项目-一种新的具有PET水解活性的角质酶的结构与功能探究(编号2021T1140141),18万,主持,已结题
2. 2022年广东省科学技术厅重点项目“功能性内酯与手性香料绿色制备关键技术研发与示范”,300万,主持子课题一“内酯与手性香料生物加工专用酶的研发”。子项目主持,在研。
代表论文:
1. Structure and ligand binding of the glutamine-II riboswitch. 2019, Nucleic acids research 47 (14), 7666-7675. L Huang#, J Wang#, AM Watkins, R Das, DMJ Lilley*. (Co-first) IF:19.16
2. The k-junction motif in RNA structure. 2014, Nucleic acids research 42 (8), 5322-5331. J Wang#, P Daldrop, L Huang, DMJ Lilley* IF:19.16
3. Engineered lipase from Janibacter sp. with high thermal stability to efficiently produce long-medium long triacylglycerols, 2022, LWT-Food Science and Technology, volumn 165, 113675 Ruiguo Cui, Xinyi Che, Lilang Li, Dongxiao Sun-Waterhouse, Jia Wang* and Yonghua Wang*. (共同通讯作者) IF:6.056
4. Structure basis for the Regiospecificity of a Lipase from Streptomyces sp. W007. 2022, International Journal of Molecular Sciences, 23(10):5822, Zexin Zhao, Siyue Chen, Long Xu, Jun Cai, Jia Wang* and Yonghua Wang *. (共同通讯作者) IF:6.208
5. The phytochemicals and health benefits of Cyclocarya paliurus (Batalin) Iljinskaja. 2023, Frontiers in Nutrition, section Food Chemistry, Volume 10 – 2023, Yingbin Shen, Peng Yao, Xucheng Zhu, Haimei Li, Liwen Zhang, Fanlei Kong, Jia Wang* and Di Yu*. (共同通讯作者) IF:6.590
6. Possible charged residue switch for acylglycerols selectivity of lipase MAS1. 2022, Applied Biochemistry and Biotechnology, on line, Yang Yang#, Jia Wang#, Dongming Lan and Yonghua Wang. (Co-first)
7. The Structure of the Guanidine-II Riboswitch. 2017, Cell Chemical Biology, 24 (6), 695-702 (Cover story). L Huang #, J Wang #, DMJ Lilley*(Co-first) IF: 9.039 Cell子刊
8. Single-molecule observation of the induction of k-turn RNA sructure on binding L7Ae protein. 2012, Biophysical Journal 103 (12), 2541-2548. J Wang, T Fessl, KT Schroeder, J Ouellet, Y Liu, ADJ Freeman, DMJ Lilley* IF: 6.1, Cell子刊
9. Solution structure of MSL2 CXC Domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases, 2012, PLOS ONE 7 (9), e45437. S Zheng#, J Wang#, Y Feng#*, J Wang, K Ye*(Co-first) IF: 3.24
联系方式:
Wangjia2@sztu.edu.cn