助理教授

个人介绍：

深圳技术大学药学院助理教授，硕士生导师，深圳市后备级人才。2017年博士毕业于复旦大学，2020年加入深圳技术大学，主要工作领域为免疫干预在疾病中的作用研究，包括天然产物的免疫药理研究、有机无机纳米杂化材料的设计合成及免疫抗肿瘤机制研究、天然产物在皮肤修复中的作用机制研究等。参与和主持了国家自然科学基金、中国博士后科学基金面上资助（一等资助）和深圳市科技计划等科研项目，已发表SCI论文10余篇。

科研项目：

1.中国博士后科学基金面上项目一等资助，肺癌抗原对DC中siglecG通路的作用及机制研究，2018.05 - 2020.03 ，主持

2.深圳市科创委自由探索项目，肺腺癌外泌体CSAG1抗原对树突状细胞siglecG抗原递呈信号通路的作用及机制研究，2019.03 -至今，主持

3.深圳市科技计划基础研究（学科布局），肺癌肿瘤干细胞疫苗的研究，2017.09 - 2020.05，主要参与人

4.国家自然科学基金项目，一种乙肝表面抗原结合蛋白对疫苗的增效剂机理研究，2014.09 - 2017.06 ，主要完成人

5.上海市科委重点科技攻关项目，快速反应增效型狂犬疫苗佐剂的研制，2014.09 - 2017.06 ，主要完成人

代表成果：

1. Qiao, L.J., Hu, W. B., Li, L. Z., Chen, X., Liu, L. P.*, Wang, J. B.*, USP11 promotes glycolysis by regulating HIF-1α stability in hepatocellular carcinoma. Journal of Cellular and Molecular Medicine, 2024. 28(2).

2. Xianjun Zhang 1, Shunzi Shao 1, Xijiang Zhao , Meng Zhang ,**, Jingbo Wang ,*，Micro-RNA-124-5p promotes insulin producing cell differentiation through regulating transcriptional factor NKX6.1，Biochemistry and Biophysics Reports 30 (2022) 101273.

3. Chen, X., Liao, B. Y., Ren, T. C., Liao, Z. P., Huang, Z. J., Lin, Y. J., Zhong, S. H., Li, J. Y., Wen, S., Li, Y. Y., Lin, X. H., Du, X. C., Yang, Y. H., Guo, J. B., Zhu, X. H., Lin, H. S. Liu, R.*, Wang, J. B*., Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model. Heliyon, 2024. 10(2).

4. Zihu Guo, liang han, Yingxue Fu, ziyi wu, yaohua ma, yueping li, haiqing wang, li jiang, shengnan liang, zhenzhong wang, Fu-Rong Li, wei xiao,Jingbo Wang*and Yonghua Wang，Systematic evaluation of the diagnostic and prognostic significance of competitive endogenous RNA networks in prostate cancer，Frontiers in genetics, 2020,doi: 10.3389/fgene.2020.00785.

5. Wang, J., Y. Wang, L. Han,M.Shahen, C. Hu and F. Li.Multi-omics integration reveals a competitive endogenous RNAs network for the identification of progression biomarkers and the stratification of patients diagnosed with nephroblastoma. Frontiers in oncology. 2020, 10,doi: 10.3389/fonc.2020.00444.

6. Wang, J., Shao, L., Wu, L., Ma, W., Zheng, Y., Hu, C. and Li F.,Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific anti-tumor immune-response in a humanized mice model.Thoracic Cancer. 2020, 39,43，doi:10.1111/1759-7714.13440.

7. Wang, J.B., X. Huang, and F.R. Li, Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives. Cancer Commun (Lond), 2019. 39(1): p. 43.

8. Wang, J., et al., Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis. Sci Rep, 2017. 7: p. 44788.

9. Wang, J.,et al., A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine. PLoS One, 2017. 12(1): p. e0170313.

10. Liu, R.#,Wang, J.#,et al., A novel rabies virus lipopeptide provides a better protection by improving the magnitude of DCs activation and T cell responses. Virus Res, 2016. 221: p. 66-73.

联系方式：

wangjingbo@sztu.edu.cn