助理教授
个人介绍：
周乐，助理教授，博士毕业于沈阳药科大学天然药物化学专业，后于香港大学从事博士后研究工作，2020年10月入职中国科学院南海海洋研究所，历任助理研究员、副研究员；2023年10月加入深圳技术大学药学院，主要从事传统中药药效物质基础研究及微生物来源活性次级代谢产物的挖掘和生物合成研究；已发表SCI论文近40篇。授权国家发明专利1件，担任Front. Chem.，J. Mar. Sci. Eng.等SCI期刊客座编辑，目前主持或参与国家及省、市级科研项目共计6项。
近年主要科研项目：
1.国家自然科学基金青年项目：海洋真菌SCSIO GtR01梭链孢烷型抗感染先导物的定向挖掘及其内酯环形成机制研究，2022.01-2024.12，30万元，主持；
2.广东省自然科学基金-面上项目：基于表观遗传修饰激活技术挖掘真菌抗革兰氏阴性菌活性物质，2022.01-2024.12，10万元，主持；
3.广州市基础与应用基础研究项目：基于LC-MS指导下的三株珊瑚附生真菌中抗MRSA活性成分的导向挖掘，2022.04-2024.03，5万元，主持；
4.国家重点研发计划青年科学家项目：深海抗癌药物先导化合物深度挖掘与活性评估的新技术研究，2022.12-2025.12，200万元，骨干成员；
5.国家自然科学基金面上项目：抗感染活性大环内酯antiracimycin的生物合成机制及其结构改造，2022.01-2025.12，60万元，在研，参与；
6.国家自然科学基金面上项目：苦木和臭椿中靶向Hsp90蛋白抑制肝癌的生物碱类成分的快速发现及作用机制研究，面上项目, 2019.01-2022.12, 57万元,资助期满,参与.
代表成果：
Zhou L.,#Bai M.,#He QJ., Hou ZL., Lu LW., Wang J., Huang XX., Lin B.,*Song SJ*. Nine new dihydro-β-agarofuran sesquiterpene polyesters from the leaves ofTripterygium wilfordii.New J. Chem., 2022, 46(5), 2423-2430.
Zhou L., Guo R., Zhang H., Lu LW., Du YQ., Liu QB., Huang XX.,*Song SJ*. Rapid approaches for assignment of the relative configuration in 1-oxygenated 1,2-diarylpropan-3-ols by1H NMR spectroscopy.J. Nat. Prod., 2021, 84: 20-25.
Zhou L., He QJ., Hou, ZL., Lu LW., Wang J., Huang XX., Lin B.,*Song SJ*. Discovery of dihydro-β-agarofurans fromTripterygium wilfordiiwith their H2O2-induced SH-SY5Y cell protective effects.Bioorg. Chem., 2020, 104, 104247.
Zhou L.,#Yao GD.,#Lu LW., Song XY., Lin B., Wang X.B., Huang XX.,*Song SJ*. Neolignans from red raspberry (Rubus idaeusL.) exhibit enantioselective neuroprotective effects against H2O2‑induced oxidative injury in SH-SY5Y cells.J. Agric. Food Chem., 2018, 66, 11390–11397.
Zhou L.,#Yao GD.,#Song, XY., Wang J., Lin B., Wang XB., Huang XX.,*Song SJ*. Neuroprotective effects of 1,2-diarylpropane type phenylpropanoid enantiomers from red raspberry against H2O2‑induced oxidative stress in human neuroblastoma SH-SY5Y cells.J. Agric. Food Chem., 2018, 66, 331–338.
Zhou L.,#He QJ.,#Lu LW., Zhao F., Zhang Y., Huang XX., Lin B.,*Song SJ*. Tripterfordins A–O, dihydro-β-agarofuran sesquiterpenoids from the leaves ofTripterygium wilfordii.J. Nat. Prod., 2019, 82, 2696–2706.
Zhou L., Han FY., Lu LW., Yao GD., Zhang YY., Wang XB., Lin B., Huang XX.,*Song SJ*. Isolation of enantiomeric furolactones and furofurans fromRubus idaeusL. with neuroprotective activities.Phytochemistry2019, 164, 122–129.
Zhou L., Wang J., Guo R., Lin B., Wang XB., Huang XX.,*Song S.J*. Discovery of dihydrobenzofuran neolignans fromRubus ideausL. with enantioselective anti-Aβ1-42aggregation activity.Bioorg. Chem., 2018, 80, 64–69.
Zhou L., Lou LL., Wang, W., Lin B., Chen JN., Wang XB., Huang XX.,*Song SJ*. Enantiomeric 8-O-4′ type neolignans from red raspberry as potential inhibitors of β-amyloid aggregation.J. Funct. Foods2017, 37, 322–329.
Zhou L., Xi YF., Wang W., Lin B., Wang XB., Huang XX.,*Song SJ*. Chiral resolution and bioactivity of enantiomeric benzofuran neolignans from the fruit ofRubus ideausL.Fitoterapia2018, 127, 56–61.
He QJ.,#Zhou L.,#Lu LW., Zhao F., Huang XX., Lin B.,*Song SJ*. Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves ofTripterygium wilfordii.Bioorg. Chem., 2019, 92, 103288.
Lu LW.,#Zhou L.,#Hou ZL. Wang J., Yao GD., Lin B., Huang XX.,*Song SJ*. Chiral-phase resolution of sesquilignans from raspberries (Rubus idaeusL.) and their neuroprotective effects.Fitoterapia2020, 146, 104655.
Wang J.,#Zhou L.,#Chen ZY., Wang YX., Yan ZY., Huang XX.,*Song SJ*. Chiral resolution and bioactivity of enantiomeric furofuran lignans fromJuglans mandshuricaMaxim.Nat. Prod. Res., 2020, 34, 2225-2228.
Xu H.#Zhou L.#Wang MZ., Wei LN., Qu HJ., Ma JY., Ju JH., Han ZW. Chemical constituents from marine derived fungusTalaromyces cellulolyticusSHJ-3 and its chemotaxonomic significance.Biochem. Syst. Ecol., 2022, 100, 104377.
联系方式：
zhoule@sztu.edu.cn
