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陈国庆

发布时间: 2025-10-27 浏览次数:

陈国庆,博士,现深圳技术大学药学院助理教授。本科毕业于西南农业大学(现年大学),硕士毕业于西南大学,博士毕业于香港浸会大学。2017420194美国纪念斯隆凯特琳癌症中心从事博士后研究。曾任职于重庆市中药研究院、香港理工大学深圳研究院。20251月加入深圳技术大学药学院。

主要研究方向包括:(1)中药及其活性成分的抗肿瘤作用机制;(2)细胞死亡调控与肿瘤发生发展;(3)中医药大健康产品研发与转化。

主持和参与了多项国家及省部级项目,以及多项企业合作的科研项目。已发表研究论文30余篇,获授权美国发明专利1项目,欧洲发明专利1项,中国发明专利20余项。现任广东省中医药学会中药实验药理专业委员会委员及深圳市科技创新委员会评审专家。

代表性论文:

[1] Teng C#, Chen JW#, Shen LS, Lin Z, Lin YS, He WY, Yuan ZH, Yang ZX, Liu YX, Lei YB, Zhang H*, Chen S*, Chen GQ*. Arnicolide C induces ROS-mediated modulation of PI3K/Akt and MAPK pathways to suppress MYC in hepatocellular carcinoma. Phytomedicine. 2025, 148, 157423 (中科院一区TOPIF=8.3)

[2] Zhang H, Gong RH, Lin YS, Wang T, Luo D, Li J, Shen LS, Wong WY*, Chen S*, Chen GQ*. Shikonin-Cu(II) Supramolecular Polymers Exhibit Antitumor Activity via Necrosis and Cuproptosis. Advanced Healthcare Materials. 2025, 14, 2403668(中科院二区TOP, IF=10.0

[3] Teng C, Chen JW, Shen LS, Chen S, Chen GQ*. Research advances in natural sesquiterpene lactones: overcoming cancer drug resistance through modulation of key signaling pathways. Cancer Drug Resistance. 2025,8:13Q1, IF=5.2

[4] Zeng YB, Deng X, Shen LS, Yang Y, Zhou X, Ye L, Chen S*, Yang DJ*, Chen GQ*. Advances in plant-derived extracellular vesicles: isolation, composition, and biological functions. Food & Function. 2024, 15,11319-11341(中科院二区TOP, IF=5.4, 封面文章)

[5] Shen LS, Chen JW, Gong RH, Lin Z, Lin YS, Qiao XF, Hu QM, Yang Y*, Chen S*, Chen GQ*. β,β-Dimethylacrylalkannin, a key component of Zicao, induces cell cycle arrest and necrosis in hepatocellular carcinoma cells. Phytomedicine. 2024, 134, 155959 (中科院一区TOPIF=8.3)

[6] Lin YS#, Sun ZW#, Shen LS, Gong RH, Chen JW, Xu Y, Yu H, Chen S*, Chen GQ*. Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells. Cell Death Discovery. 2024, 10, 134(中科院二区TOP, IF=7.0

[7] Gong RH#, Chen JW#, Shen LS, Lin YS, Yu H, Chen S*, Chen GQ*. Assessing the therapeutic potential of Elephantopus scaber extract in hepatocellular carcinoma by inhibiting the PI3K-Akt pathway. Journal of Functional Foods. 2024; 113:106009 (中科院二区, IF=4.0)

[8] Chen GQ#, F. A Benthani#, Wu J, Liang D, Bian ZX*, Jiang X*. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis, Cell Death & Differentiation. 2020, 27, 242-254(中科院一区TOP, IF=15.4[截止202510月,他引次数420次,数据来源google scholar]

[9] Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH*, Bian ZX*. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer, Cell Death & Disease. 8 (2017) e2789(中科院一区TOP, IF=9.6


 

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