助理教授

个人介绍：

姚大红，深圳技术大学药学院助理教授。2012年毕业于沈阳药科大学，获药学理学学士学位，于2015年沈阳药科大学获药学硕士学位，于2015-2018年沈阳药科大学与四川大学生物治疗国家重点实验室联合培养获药物化学博士学位，2019年至2020年于深圳大学师从杨宝峰院士-贺震旦教授从事博士后研究工作，主要从事三阴性乳腺癌新型靶向小分子药物的设计合成。

科研项目：

1.博士后面上一等，ATAD2抑制剂的设计合成及抗三阴性乳腺癌的机制研究（2019M650213），2019-2020，主持。

2.科技部重大专项-重大新药创制子课题，中药民族药组分资源库建设（2018ZX09735-005），主持。

3.广东省基础与应用基础研究青年基金，靶向ATAD2小分子抑制剂设计合成及抗三阴性乳腺癌作用机制研究（2019A1515110482），2020.01-2022.12，主持。

4.深圳市基础研究面上项目，基于结构的靶向ATAD2小分子抑制剂设计合成及抗三阴性乳腺癌作用机制研究（JCYJ20190808171803553），2020.02-2023.02，主持。

5.国家自然科学基金青年项目，双靶向ATAD2/PAK1抗三阴性乳腺癌的小分子抑制剂的设计合成及机制研究（82003580），2021.01-2023.12，24万，主持。

代表成果：

(1)Dahong Yao^#, Chenyang Li^#, Muhammad Shahid Riaz Rajoka, Zhendan He, Jian Huang, Jinhui Wang4*, Jin Zhang1,3*. P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in cancer. Theranostics. 2020. doi:10.7150/thno.46913.

(2)Dahong Yao, Dabo Pan, Yongqi Zhen, Jian Huang, Jinhui Wang^*, Jin Zhang^*, Zhendan He^*.Ferulin Ctriggerspotent PAK1 and p21-mediated anti-tumor effects in breast cancer by inhibiting Tubulin polymerizationin vitroandin vivo, Pharmacol Res.2020, 152:104605.

(3) Dahong Yao^#, Chenyang Li^#, Jin Jiang, Jian huang, Jinhui Wang, Zhendan He*, Jin Zhang*. Design, Synthesis and Biological evaluation of novel HDAC Inhibitors with improved pharmacokinetic profile in breast cancer, Eur J Med Chem,2020,112648(Q1,IF = 5.572)

(4) Jin Zhang*, Ling Zou, Pan Tang, Dabo Pan,Zhendan He,Dahong Yao^*.Design, Synthesis and biological evaluation of1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells,Eur J Med Chem,2020,112220.

(5)Dahong Yao, Jian huang, Jinhui Wang, Zhendan He*, Jin Zhang*. Design, synthesis and biological evaluation of novel tetrahydrothieno [2,3-c]pyridine substitued benzoyl thiourea derivatives as PAK1 inhibitors in triple negative breast cancer. J ENZYM INHIB MED CH.2020, 35(1): 1524-1538.

(6)Dahong Yao, Jin Zhang, Jinhui Wang, Dabo Pan^*, Zhendan He^*. Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening. J ENZYM INHIB MED CH.2020, 35(1): 713-725.

(7)Dahong Yao^#, Yuxin Zhou, Linjuan Zhu, Liang Ouyang, Jin Zhang, Yingnan Jiang, Yuqian Zhao, Dejuan Sun, Shilin Yang^*, Yang Yu^*, Jinhui Wang.Design, synthesis and structure-activity relationship studies of a focused library of pyrimidine moiety with anti-proliferative and anti-metastasis activities in triple negative breast cancer, Eur J Med Chem,2017, 140:155-171.

(8)Dahong Yao^#, Jie Liu, Liang Ouyang^*. What structural modifications can be used for BRD4 inhibitors for their use in leukemia therapy?Future Med Chem,2017, 9(9):839-842.

(9)Dahong Yao^#, Yinnan Jiang, Suyu Gao, Lei Shang, Yuqian Zhao, Jian Huang, Jinhui Wang^*, Shilin Yang^*, Lixia Chen^*. Deconvoluting the complexity of microRNAs in autophagy to improve potential cancer therapy,Cell Prolif,2016, 49(5):541-53.

(10)Dahong Yao^#, Jing Wang, Guan Wang, Yinnan Jiang, Lei Shang, Yuqian Zhao, Jian Huang, Shilin Yang^*, Jinhui Wang^*, Yamei Yu^*. Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells,Bioorg Chem,2016, 68:112-23.

(11)Dahong Yao^#, Peiqi Wang, Jin Zhang, Leilei Fu, Liang Ouyang^*, Jinhui Wang^*. Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy, Apoptosis,2016, 21(6):683-98.

(12)Dahong Yao^#,Ruhan A^#, Jin Jiang, Jian Huang, Jinhui Wang*, Weina Han*. Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells, Bioorg Med Chem Lett. 2020, 30:127355. (Q3,IF = 2.572)

(13) Jin Zhang^#,Dahong Yao^#, Yinnan Jiang, Jian Huang, Shilin Yang^*, Jinhui Wang^*.Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells, Bioorg Chem,2017, 72:168-181.

(14) Xin X^#,Yao D^#, Zhang K^*, Han S, Liu D, Wang H, Liu X, Li G, Huang J, Wang J^*.Protective effects of Rosavin on bleomycin-induced pulmonary fibrosis via suppressing fibrotic and inflammatory signaling pathways in mice.Biomed Pharmacother,2019, 115:108870.

联系方式：

yaodahong@sztu.edu.cn